MR 氫質子波譜在乳腺腫塊應用中的價值及
技術干擾因素分析
趙斌 蔡世峰 于臺飛 彭洪娟 李慧華
【摘要】 目的 探討MR 氫質子波譜( 1 H-MRS) 在乳腺腫塊中的應用價值及技術干擾因素。
方法 回顧性分析手術后經病理證實的47 個乳腺腫塊的1H-MRS 特征。其中惡性腫瘤24 個, 良性腫
瘤23 個, 均于增強掃描前行1H-MRS 檢測。結果 24 個惡性病灶中11 個于3. 24 ppm( × 10 - 6 ) 處出
現膽堿( Cho) 共振峰。23 個良性病變中4 個于3. 24 ppm 處出現Cho 共振峰。以1H-MRS Cho 峰鑒別
乳腺腫塊良惡性, 敏感性為45. 8% , 特異性為82. 6% 。結論 1 H-MRS 檢測到Cho 并非乳腺惡性病變
的特異表現。不論良性或惡性病變, 只要在短期內迅速生長, 1H-MRS 即可測得Cho。檢出率較低的
原因主要為技術因素。
【關鍵詞】 乳腺疾病; 乳腺腫瘤; 磁共振波譜學; 病理學
Study of clinica l value and influencing fa ctors of 1H-MR spectr oscopy in mammar y tumors
ZHAO Bin* , CAI Shi-feng, YU Tai-fei, PENG Hong-jua n, LI Hui-hua. * Shandong Medica l Imaging
Research Institute, Jinan 250021, China
【Abstra ct 】 Object ive To investigate the diagnostic value of 1H magnetic resonance spectroscopy
( 1H-MRS) in mammary tumors and to discuss the technique factors which influence the detection
rate. Methods The 1H-MRS features of 47 mammary tumors , of which 24 malignant tumors and 23 benign
tumors confirmed by pathology were analyzed. All of the tumors were detected before Gd-DTPA
enhancement. Results Eleven of 24 malignant tumors showed increased choline resonance peak at
3. 24 ppm while 4 of 23 benign ones at 3. 24 ppm . The positive value were 45. 8% and 17. 4% respectively.
The sensitivity and specificity were 45. 8% and 82. 6% respectively by using 1H-MRS to discriminate benign
from malignant tumors. The main factors influencing the detection rate were low suppressed lipid, low
suppressed water and low single-noise rate. Conclusion Choline is not special features of malignant tumors.
Choline can be obtained despite the nature of tumor if they grow rapidly. The low sensitivity of choline to be
detected mainly dues to technique factors.
【Key wor ds】 Breast diseases ; Breast neoplasms; Magnetic resonance spectroscopy; Pathology

MR 氫質子波譜在乳腺腫塊應用中的價值及--乳腺.rar