一種用于細胞培養(yǎng)的新型植物來源的重組生長因子，將會提升產(chǎn)量和安全性。

該產(chǎn)品被稱為Lacromin，是一種來源于植物的重組人乳鐵蛋白，這種因子要優(yōu)于通常使用的動物來源生長因子轉(zhuǎn)鐵蛋白。Lacromin是Ventria生物科學公司的產(chǎn)品。

Lacromin是一種強大的生長因子，能夠促進許多細胞株的生長，包括中國地鼠卵巢細胞和小鼠雜交瘤細胞。它還能夠提高細胞密度，與轉(zhuǎn)鐵蛋白相比，能夠較少細胞增殖一倍的時間。因為Lacromin來自植物，所以沒有任何病毒和或者朊病毒污染的危險。在雜交瘤細胞株中，與使用轉(zhuǎn)鐵蛋白相比，Lacromin能夠?qū)gG產(chǎn)量增加50％，與胎牛血清相比，增加6％。

“我們對Lacromin的這些結(jié)果感到十分鼓舞。”Ventria生物科學公司研究與開發(fā)部副總裁Ning Huang如此評論。Huang先生2005年7月在堪薩斯市舉行的“哺乳動物細胞培養(yǎng)產(chǎn)品原材料和一次性處理系統(tǒng)大會”上介紹了Lacromin。“在今天的會議上，我報道的結(jié)果顯示：與動物來源的轉(zhuǎn)鐵蛋白相比較，Lacromin能夠顯著增加抗體的產(chǎn)量。”

該公司將會把Lacromin推介給那些尋求無血清和無動物成分的細胞培養(yǎng)基的公司。
 
Plant-Derived Culture Media
 
A new plant-derived recombinant growth factor for cell culture media promotes productivity and safety.

Called Lacromin, the growth factor is a recombinant human lactoferrin derived from plants, which outperforms transferrin, a common animal-derived growth factor. Lacromin is the product of Ventria Bioscience (Sacramento, CA, USA).

Lacromin is a strong growth factor that has promoted cell growth in many cell lines, including Chinese hamster ovary (CHO) cells and mouse hybridoma cells. The growth factor also promotes higher cell density and reduces cell doubling time when compared to transferrin. Since Lacromin is derived from plants, it is free of any viral or prion containment risks. In hybriderma cells, Lacromin increased IgG productivity by 50% compared to transferrin and by 6% compared to fetal bovine serum (FBS).

“We are very encouraged by the positive results we have generated on Lacromin,” said Ning Huang, vice president of research and development, Ventria Bioscience. Mr. Huang introduced Lacromin at the Raw Materials and Disposable Process Systems for Mammalian Cell Culture Products Conference in Kansas City (MO, USA) in July 2005. “At the conference today, I presented results showing Lacromin significantly increased the productivity of antibody production when compared with animal-derived transferrin.”

The company will market Lacromin to companies seeking a serum-free and animal component-free cell culture media source.