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首頁(yè) > 美迪醫(yī)訊 > 純氧可對(duì)大腦造成損傷 |
純氧可對(duì)大腦造成損傷 【?2007-06-08 發(fā)布?】 美迪醫(yī)訊
最新的研究表明吸入純氧實(shí)際上能損傷大腦,在純氧中摻入二氧化碳可以保護(hù)病人的大腦。 美國(guó)加利福尼亞大學(xué)的研究學(xué)者使用MRI獲取詳細(xì)的圖像資料,關(guān)于兩個(gè)不同呼吸組大腦中發(fā)生的變化。研究學(xué)者掃描了14個(gè)健康兒童的大腦,這些兒童的年齡在8到15歲,并且監(jiān)測(cè)當(dāng)他們通過(guò)特殊裝置吸入100%純氧2分鐘后呼吸和心率的變化。8分鐘后直到最小的兒童呼吸恢復(fù)到正常,一組研究對(duì)象在所呼吸的氧氣中添加5%的二氧化碳,并重復(fù)剛才的掃描工作。對(duì)照組和研究組的比較表明兩者間存在顯著的差別。 第一作者神經(jīng)生物學(xué)專家Ronald Harper解釋說(shuō),大腦中的很多部分都會(huì)對(duì)100%純氧做出反應(yīng),并且最終刺激下丘腦。下丘腦當(dāng)血液中出現(xiàn)大量激素和神經(jīng)轉(zhuǎn)運(yùn)體時(shí)會(huì)過(guò)度反應(yīng)。這些化學(xué)物質(zhì)可干擾心臟泵血的穩(wěn)定性,而純氧在復(fù)蘇病人的同時(shí)可能產(chǎn)生相反的效應(yīng)。 然而,當(dāng)研究對(duì)象吸入含有二氧化碳混合氣體后,通過(guò)MRI監(jiān)測(cè)發(fā)現(xiàn)下丘腦的高反應(yīng)性消失。研究學(xué)者得出結(jié)論,純氧中的二氧化碳能擴(kuò)張血管,使氧氣能到達(dá)心臟和大腦,使下丘腦恢復(fù)刺激前的狀態(tài)并且減慢危險(xiǎn)性化學(xué)物質(zhì)的釋放速率。這項(xiàng)研究出版于PLoS醫(yī)學(xué)版雜志2007年5月號(hào)。 基于他們的發(fā)現(xiàn),大大促進(jìn)健康醫(yī)療部門在純氧中添加二氧化碳成分,尤其是在嬰兒復(fù)蘇以及吸入純氧一段時(shí)間后。這種指導(dǎo)性治療方法可運(yùn)用于休克、心臟損傷、一氧化碳中毒以及長(zhǎng)時(shí)氧氣等方面的治療。 來(lái)源:medinews.com Pure Oxygen Can Damage the Brain New research suggests that inhaling pure oxygen can actually harm the brain, and recommends adding carbon dioxide to the mix to preserve brain function in patients. Researchers at the University of California, Los Angeles (UCLA; USA) used functional magnetic resonance imaging (fMRI) to capture detailed imagesof what occurs inside the human brain during two different breathing scenarios. The researchers scanned the brains of 14 healthy children, ages 8 to 15, and monitored their breathing and heart rates as they inhaled 100% oxygen through a mouthpiece for two minutes. After waiting eight minutes for the youngsters’ breathing to return to normal, the team added 5% carbon dioxide to the gas mixture and repeated the scan. A comparison of the two scans revealed dramatic differences. everal brain areas responded to 100% oxygen by kicking the hypothalamus into overdrive,?explained lead author Ronald Harper, a professor of neurobiology at the David Geffen School of Medicine at UCLA. 揟he hypothalamus overreacted by dumping a massive flood of hormones and neurotransmitters into the bloodstream. These chemicals interfere with the heart’s ability to pump blood and deliver oxygen--the opposite effect you want when you’re trying to resuscitate someone.? However, when the children inhaled the carbon dioxide-oxygen mix, the hypothalamus’ hyperactivity vanished from the MRI scan. The researchers concluded that adding carbon dioxide to the oxygen relaxed the blood vessels, allowed oxygen to reach the heart and brain, calmed the hypothalamus, and slowed the release of the dangerous chemicals. The study was published in the May 22, 2007, edition of the journal Public Library of Science (PLoS) Medicine. Based on their findings, the researchers strongly encourage health care providers to add carbon dioxide to oxygen dispensation, especially when resuscitating infants or administering oxygen for more than a few minutes. The new direction could hold particular implications for patients of stroke, heart attack, carbon monoxide poisoning, and any long-term oxygen therapy. Related Links: University of California, Los Angeles 《美迪醫(yī)訊》歡迎您參與新聞投稿,業(yè)務(wù)咨詢: 美迪醫(yī)療網(wǎng)業(yè)務(wù)咨詢
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