關(guān)于冠狀動(dòng)脈旁路手術(shù)對(duì)記憶以及其他大腦功能影響的回顧性研究顯示：盡管手術(shù)可能具有暫時(shí)的短期效應(yīng)，該手術(shù)可能不會(huì)導(dǎo)致后期的或者持久的神經(jīng)系統(tǒng)缺陷。

研究人員發(fā)現(xiàn)：在某些長(zhǎng)期研究中觀察到的后期認(rèn)知下降可能與原有疾病的進(jìn)展有關(guān)，例如腦血管疾病，而不是手術(shù)本身的作用。而例外情況包括老年患者和那些具有腦血管疾病風(fēng)險(xiǎn)的患者或者出現(xiàn)過(guò)腦卒中發(fā)作史的患者。

令人感興趣的研究證實(shí)：在手術(shù)之后3個(gè)月的時(shí)間內(nèi)出現(xiàn)輕微病變，這是由于血流輕度紊亂或者其他手術(shù)相關(guān)因素造成的，諸如炎癥或者麻醉。當(dāng)研究人員檢查最權(quán)威試驗(yàn)研究的時(shí)候，他們?cè)诖蠖鄶?shù)患者3個(gè)月之后，沒(méi)有發(fā)現(xiàn)支持認(rèn)知缺陷的強(qiáng)有力證據(jù)。

Johns Hopkins醫(yī)院神經(jīng)病學(xué)教授Ola Seines博士說(shuō)：“我們考慮在某些亞群患者冠狀動(dòng)脈旁路移植手術(shù)之后，存在短期認(rèn)知缺陷，但是沒(méi)有明顯的腦卒中發(fā)作，而這些病變通常是輕微暫時(shí)的。”

作者說(shuō)，研究中發(fā)現(xiàn)的認(rèn)知功能缺陷一個(gè)可能原因，是接受旁路手術(shù)的人群變得更加衰老與虛弱，患高血壓、糖尿病、先兆腦卒中以及其他疾病的機(jī)會(huì)更多。

Seines博士說(shuō)：“我們相信接受冠狀動(dòng)脈旁路移植手術(shù)的患者，不應(yīng)當(dāng)為后期可能出現(xiàn)的認(rèn)知功能缺陷而感到沮喪。”
 
Bypass Surgery May Not Affect Brain Function
 
A broad retrospective review of the effects of coronary bypass surgery on memory and other brain functions has shown that while there may be transient short-term effects, the procedure probably does not cause late or permanent neurologic defects.

The researchers found that the late cognitive declines seen in some long-term studies are likely associated with the progression of underlying conditions, such as cerebrovascular disease, rather than the surgery itself. The exceptions might include older patients and those with risk factors for cerebrovascular disease or a history of stroke.

Existing studies confirm the existence of mild deficits in the period up to three months after surgery, which may be due to minor disruption in blood flow or other surgery-related factors, such as inflammation or anesthesia. When the researchers examined the most authoritative studies, they failed to find strong evidence that cognitive deficits persist after three months in most patients.

“We think that there are short-term cognitive changes after coronary artery bypass grafting (CABG) in a subset of patients, but absent a frank stroke, these changes are generally mild and transient,” said author Ola Seines, Ph.D., professor of neurology at Johns Hopkins Hospital (Baltimore, MD, USA).

One possible cause of the cognitive defects found in studies, say the authors, may be the fact that the population having bypass surgery is becoming older and sicker, with more hypertension, diabetes, previous strokes, and other disorders.

“We believe that patients should not be discouraged from having CABG because of the risk of late cognitive function,” added Dr. Seines.