在一項(xiàng)對(duì)由于氣促而到急診室就醫(yī)的1256例患者的臨床研究中，證實(shí)了血液氨基酸末端親腦利納肽(NT-proBNP)在診斷疑似急性心衰的價(jià)值。

先前的研究已經(jīng)證實(shí)這個(gè)指標(biāo)的價(jià)值，但是局限在單中心而且患者數(shù)量較少。在當(dāng)前研究中的720例患者被診斷為急性心衰，NT-proBNP中位數(shù)水平大大高于那些不是急性心衰的患者。當(dāng)癥狀嚴(yán)重程度增加的時(shí)候，NT-proBNP的水平也升高。NT-proBNP是心臟激素BNP的生物無活性前體。許多先前的研究顯示BNP是診斷充血性心臟衰竭的指標(biāo)。

這項(xiàng)研究是在新西蘭、西班牙和荷蘭進(jìn)行的。與那些水平較低的患者相比較，NT-proBNP水平超過5,180 pg/ml的患者在研究期間死亡風(fēng)險(xiǎn)升高5倍。這項(xiàng)研究結(jié)果在2005年11月17日《歐洲心臟期刊》在線版上進(jìn)行了報(bào)道。

Blood Test Confirmed Useful for Heart Failure
 
A study involving 1,256 patients arriving at emergency rooms with shortness of breath has confirmed the value of a blood test for amino-terminal pro-brain natriuretic peptide (NT-proBNP) for diagnosing suspected acute heart failure.

Prior studies have suggested this usefulness but were restricted to single centers and a small number of patients. In 720 of the current patients, who were diagnosed with acute heart failure, median NT-proBNP levels were considerably higher compared to patients who did not have acute heart failure. As the severity of symptoms rose, levels of NT-proBNP also rose. NT-proBNP is the biologically inert precursor to the heart hormone BNP. Many previous studies have shown BNP as a marker in the diagnosis of congestive heart failure.

The patients in the new study were in New Zealand, Spain, and the Netherlands. Those whose levels of NT-proBNP were greater than 5,180 pg/ml were found to have a fivefold increased risk of death within the study period, compared to patients whose levels were low. The study’s findings were reported in the November 17, 2005, online edition of the European Heart Journal.