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睪酮水平與突發(fā)性嬰兒死亡綜合征有關(guān)

【?2005-12-14 發(fā)布?】 美迪醫(yī)訊
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在一項最新研究中,一項尸體解剖后的血液分析顯示,死于突發(fā)嬰兒死亡綜合征(SIDS)的男性嬰兒睪酮水平顯著高于作為對照的嬰兒。

這項研究包括了127例SIDS尸體解剖和42例對照。SIDS男性嬰兒睪酮水平比男性對照要高120%。女性SIDS嬰兒的睪酮水平比女性對照要高50%。另一方面,雌二醇水平在兩個組中都不顯著。這些結(jié)果報道在2005年11月《兒科學期刊》之上。

作者指出早期動物實驗和人體研究顯示,睪酮水平升高與睡眠中的呼吸抑制有關(guān)。

作者還指出,在出生后性激素水平升高與SIDS風險年齡范圍之間有著“驚人的巧合”,高峰都出現(xiàn)在1月齡和5月齡。他們承認他們的研究樣本較小,需要更多的研究來探討睪酮素水平升高與SIDS之間的關(guān)系。

Testosterone Level Linked to SIDS
 
In a new study, a postmortem blood analysis showed that male babies who died of sudden infant death syndrome (SIDS) had testosterone levels that were much higher than those of control babies.

The study involved 127 SIDS autopsies and 42 controls. The SIDS males had testosterone levels that were 120% higher than the male controls. Testosterone levels in female SIDS babies were 50% higher than the female controls. Estradiol levels, on the other hand, were not significant in either group. The findings were reported in the November 2005 issue of the Journal of Pediatrics.

The authors noted that earlier evidence in animal models and human studies had suggested that elevated testosterone levels may be linked to breathing that is depressed in sleep.

The authors also noted that there is “a striking coincidence” between postnatal rises in the sex hormones and the age range of risk for SIDS, with both peaking between one and five months of age. They acknowledged that their study sample was small and that more research is needed to understand the relationship between high testosterone and SIDS.

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