在一項前瞻性、多中心臨床研究中發現，一種使用糞便中DNA的非創傷性大腸癌篩查方法，其敏感性達到了88%。

在2006年5月美國洛杉磯(CA, USA)舉行的消化疾病周(DDW)年度會議上報道了這項研究結果，DDW是一項國際胃腸病學專家的盛會。采用盲法研究主要是為了驗證該技術的效果，以提高糞便樣本中大腸癌的檢出率。

使用經過簡化的基因標志物檢測盤、DNA穩定緩沖液、DNA增強捕獲技術，Exact科學公司(Marlborough, MA., USA)的第2代糞便DNA技術，在這項采用盲法設計的臨床研究中，結腸癌的檢測敏感性達到了88%。該研究還證實了第1代糞便DNA檢測技術如果使用DNA緩沖液之后，敏感性可以達到73%。
 
Colon Cancer Screening Based on Stool DNA
 
A non-invasive screening method for colon cancer using stool DNA demonstrated 88% sensitivity in a prospective, multi-center study.

The results of the study were presented at the annual Digestive Disease Week (DDW) conference in May 2006 in Los Angeles (CA, USA) , an international meeting of gastroenterology professionals. The blinded study was designed to test the efficacy of technologic advances to enhance colorectal-cancer detection in stool samples.

Using a simplified panel of genetic markers, a buffer for DNA stabilization, and an enhanced DNA capture technology, Exact Sciences’ (Marlborough, MA., USA) second generation stool DNA technology demonstrated 88% sensitivity for colorectal cancer in this blinded study. The study also confirmed that the first generation stool DNA technology demonstrated a sensitivity of 73% with use of the DNA stabilization buffer.