四種獨(dú)特的診斷基因表達(dá)譜檢測(cè)精神分裂癥/煩躁抑郁雙向疾病患者的血標(biāo)本，具有統(tǒng)計(jì)學(xué)差異(p< 0.001)。

對(duì)115例精神分裂癥/煩躁抑郁雙向疾病患者和匹配對(duì)照患者的基因進(jìn)行分析。分析結(jié)果顯示：每個(gè)患者/對(duì)照4組亞組種只有1組相同，每一亞組都與一種獨(dú)特而有限數(shù)量的基因相關(guān)。每一亞組中發(fā)現(xiàn)的基因包括已知的和新的藥物靶標(biāo)與生物標(biāo)記，血液檢測(cè)的特異性和敏感性都進(jìn)行了檢測(cè)。

血液檢測(cè)結(jié)果與兩種獨(dú)立的Curidium (London, UK)使用該公司的工具Homomatrix大腦研究結(jié)果相一致。Homomatrix是一種全自動(dòng)檢測(cè)工具，使用了模式識(shí)別工具和數(shù)學(xué)運(yùn)算法則序列以及統(tǒng)計(jì)方法，將來(lái)自異質(zhì)人群的海量基因表達(dá)和生物資料進(jìn)行客觀分析。這些檢測(cè)能夠促進(jìn)治療-應(yīng)答和/或者患者亞組診斷方法、信號(hào)途徑和藥物靶標(biāo)的開(kāi)發(fā)。

Gene Expression Profiles in Blood Diagnosed Mental Illness
 
Four unique and statistically significantly different (p< 0.001) diagnostic gene expression profiles were identified in blood samples from schizophrenia/bipolar disorder patients.

The gene expression profiles of 115 schizophrenia/bipolar disorder patients and matched controls were analyzed. The result of this analysis showed that each patient/control was a member of only one of four subgroups and each subgroup was associated with a unique and finite number of genes. The genes identified in each subgroup include known and novel drug targets and biomarkers, and the specificity and sensitivity of a potential blood diagnostic test are being determined.

These results in blood are in line with the results from two separate Curidium (London, UK) brain studies using the company’s tool Homomatrix. Homomatrix is a fully automated analysis tool that uses proprietary pattern recognition tools and sequences of mathematic algorithms together with statistical methods to objectively analyze large sets of gene expression and biological data from heterogeneous populations. These analyses can potentially lead to the development of diagnostics that identify treatment-responsive patients and/or patient subgroups, signaling pathways as well as drug targets.