根據2004年11月發(fā)表在《美國手術期刊》的報道，使用Zyvox治療甲氧苯青霉素耐藥金黃色葡萄球菌感染手術患者的成功率是87％，而使用萬古霉素治療成功率是48％。

手術部位感染患者有60％的可能在重癥監(jiān)護室度過，重新入院治療的可能性增加了5倍，死亡可能增加了2倍。數據顯示2000年MRSA導致了美國醫(yī)院30％手術部位感染，而1997年只有24％。在該項研究中，大多數患者接受了靜脈制劑的Zyvox。盡管總體治療時間相似，但是患者使用Zybox靜脈治療平均時間顯著少于萬古霉素患者（4.7天vs11.1天）

The subset analysis of 135 patients with surgical site infections was taken from a large, randomized, multicenter trial of 1,200 patients designed to compare the clinical efficacy and safety of Zyvox (Pfizer, Inc.).
對一項比較Zyvox臨床效能與安全性的大規(guī)模隨機多中心臨床試驗1200例患者中的135例手術部位感染的患者進行了亞類分析。

威斯康星州外科副主任、教授、首席研究員John Weiglt教授說：“由于MRSA導致的手術部位感染的流行率不斷增高，早期鑒別MRSA感染以及尋找萬古霉素的替代藥物的任務迫在眉睫，因為任何接受手術的患者都處于危險之中。”

Zyvox Best for MRSA Surgical Site Infections
 
Surgical patients treated for methicillin-resistant Staphylococcus aureus (MRSA) with Zyvox (linesolid) showed success rates of 87% compared to 48% for patients treated with vancomycin, according to a new study published in the December 2004 issue of the American Journal of Surgery.

Patients who develop surgical site infections are 60% more likely to spend time in an intensive care unit, five times more likely to be re-admitted to the hospital, and twice as likely to die. Data show that MRSA caused 30% of surgical site infections in U.S. hospitals in 2000, compared to 24% in 1997. In the study, most patients received the intravenous (IV) formulation of Zyvox. Although the total length of treatment among groups was comparable, the mean duration of IV treatment was significantly shorter for Zyvox patients than for vancomycin patients (4.7 days vs 11.1 days, respectively).

The subset analysis of 135 patients with surgical site infections was taken from a large, randomized, multicenter trial of 1,200 patients designed to compare the clinical efficacy and safety of Zyvox (Pfizer, Inc.).

“As the prevalence of surgical site infections caused by MRSA increases, identifying MRSA early and having alternatives to vancomycin become extremely important, since any patient undergoing surgery is at risk,” said lead investigator Dr. John Weigelt, professor and vice chairman of the department of surgery at the Medical College of Wisconsin (Milwaukee, USA).