對兩項減肥手術中使用的技術的研究顯示：與胃改道術相比較，billopancreatic轉移能夠將患者胰島素敏感性增加1倍。

超重患者面臨學多醫學問題，包括胰島素抵抗以及2型糖尿病。對這些患者進行減肥手術使得體重下降，而胰島素敏感性增加。在研究中，體重嚴重超標的18例非糖尿病患者與20例對照患者進行了代謝功能檢測，包括測定胰島素活性。肥胖患者接受胃改道手術（通過較小胃體積來限制食物攝入），或者Billopancreatic轉移（縮短小腸減少脂肪吸收）。患者術后5～6月以及16～24月接受隨訪。

巴西Campinas州立大學(Sao Paulo, Brazil)Alza Muscelli醫生解釋說：“在當前的研究中，胃改道手術與Billopancreatic轉移手術的生理學差異得到了探討，突出了脂質吸收障礙與胰島素活性支架的關系。但是，這些患者選擇最佳治療方案是根據風險/效益法則進行評估的。”

這項研究發表在2005年1月《美國醫學期刊》 上。其它研究人員來自羅馬Catholic大學以及Pisa大學。
 
Bariatric Technique Increases Insulin Sensitivity
 
A study of two techniques used in weight-loss surgery shows that billopancreatic diversion can double insulin sensitivity in patients, compared to gastric bypass surgery.

Excessively overweight patients can have many medical problems, including insulin resistance and often type 2 diabetes. Bariatric surgery for such patients leads to weight loss and improves insulin sensitivity. In the study, 18 nondiabetic patients with severe obesity and 20 lean subjects underwent metabolic studies, including the measurement of insulin activity. The obese patients then underwent either gastric bypass, which restricts food intake by making the stomach very small, or billopancreatic diversion, which shortens the small intestine and reduces fat absorption. Patients were followed at five to six months and again at 16-24 months after surgery.

“In the present study, the physiological difference between gastric bypass and billopancreatic diversion was exploited to highlight the link between lipid malabsorption and insulin action,” explained Alza Muscelli, M.D., of the State University of Campinas (Sao Paulo, Brazil). “However, the choice of the optimal therapeutic strategy in these patients depends on a risk/benefit algorithm to be assessed in each patient.”

The study was published in the January 2005 issue of The American Journal of Medicine. Other researchers from the Catholic University in Rome (Italy) and the University of Pisa (Italy) also participated in the study.