丁其勇 滑炎卿 管一暉 趙軍 朱鳳 毛定飚 葛虓俊 張國楨
【摘要】 目的 探討非小細胞肺癌動態CT 增強值與正電子發射計算機體層攝影( PET) 中
18 氟-脫氧葡萄糖( 18F-FDG) 標準攝取值( SUV) 的相關性。方法 搜集行PET-CT 和動態增強CT 檢查
的28 例非小細胞肺癌和13 例良性肺結節病例, 測量結節增強前后各時相的平均CT 值、18 F-FDG 標
準攝取值的最大值和平均值, 計算結節增強峰值, 用Pea rson 相關分析方法評價良惡性結節動態CT
增強峰值和18 F-FDG SUV 的相關性。結果 非小細胞肺癌和良性結節CT 增強峰值[ ( 35. 09 ±
11. 41) 、( 26. 92 ±19. 98) HU] 的差異無統計學意義( t = 1. 374, P = 0. 189) , SUV 最大值( 7. 23 ±4. 38、
2. 97 ±2. 80) 差異有統計學意義( t = - 3. 972, P < 0. 001 ) , SUV 平均值差異有統計學意義( t =
- 4. 061, P < 0. 001) 。非小細胞肺癌CT 增強峰值[ ( 35. 09 ±11. 41) HU] 和18 F-FDG SUV 的平均值
( 4. 93 ±3. 53) 及最大值( 7. 23 ±4. 38) 之間均無相關關系( r = - 0. 040, P = 0. 839 及r = 0. 056, P =
0. 778) 。結論 非小細胞肺癌動態CT 增強值與FDG SUV 之間無相關關系, FDG SUV 可能不適用于
非小細胞肺癌抗腫瘤血管生成治療的療效評價。
【關鍵詞】 肺腫瘤; 體層攝影術,X 線計算機; 體層攝影術, 發射型計算機; 氟脫氧葡萄糖F18
Corr elative investigation of dynamic contr ast CT a nd positr on emission tomogr aphy with
18-fluor odeoxy glucose standar dized uptake value in non -small cell lung cancer DING Qi-yong* ,
HUA Ya n-qing, GUAN Yi-hui, ZHAO Jun, ZHU Feng, MAO Ding-biao, GE Xia o-jun, ZHANG Guo-zhen.
* Department of Ra diology, Hua dong Hospital, Shanghai 200040, China
【Abstra ct 】 Object ive To explore the correlation of dynamic enhanced CT attenuation and
18-fluorodeoxy glucose ( 18 F-FDG ) standardized uptake value ( SUV) in non-small cell lung cancer
( NSCLC) . Met hods Twenty-eight NSCLC patients and 13 patients with benign nodules ( 28 male,
13 female; age range 15 - 79 years, median 57 years; the diameter range from 0. 8 - 4. 0 cm, mean
2. 2 cm) were examined on Siemens biograph sensation 16 PET-CT with 18F-FDG. Dynamic enhanced CT
scan was performed on Siemens sensation 16 PET-CT or 16 slice CT in 23 patients and other 18 patients had
the results of dynamic CT from other hospitals. The mean CT attenuation of ROI on precontrast and
postcontrast multi-phase images , the maxium and average SUV of 18 F-FDG were respectively measured. The
correlation between the peak attenuation( APA) and SUV was analyzed with pearson correlation coefficient
test. Result s The CT APA between NSCLC and benign nodules had no significance difference ( t = 1. 374,
P = 0. 189) . The difference of maximum and average SUV between NSCLC and benignity were significant
( t = - 3. 972, P < 0. 001 & t = - 4. 061, P < 0. 001 respectively) . No correlation was found among APA,
maximum SUV ( 7. 23 ±4. 38) , and average SUV( 4. 93 ±3. 53) ( r = - 0. 040, P = 0. 839 & r = 0. 056,
P = 0. 778) . Conclusion There is no correlation between APA and SUV in NSCLC. SUV is probably not
suitable for the evaluation of the effects of anti-angiogenesis therapy.
【Key words 】 Lung neoplasms; Tomography, X-ray computed; Tomography, emissioncomputed;
Fludeoxyglucose F18

非小細胞肺癌動態CT 增強值與正電子.rar