大腸癌腸外浸潤螺旋CT 征象與腫瘤血管生成的相關性
張瑞平 李健丁
【摘要】 目的 探討大腸癌腸外浸潤的螺旋CT( SCT) 征象與病理、腫瘤微血管密度( MVD) 、血
管內皮生長因子( VEGF) 和基質金屬蛋白酶-2( MMP-2) 表達的關系。方法 40 例大腸癌患者, 術前
均行SCT 多期動態掃描, 術后標本采用免疫組織化學方法染色, 檢測VEGF 和MMP-2 的表達和計數
MVD。結果 螺旋CT 判斷大腸癌腸外、腸壁浸潤的準確率為92. 5% ( 37 / 40) 。腸外、腸壁浸潤組的
轉移率分別為75. 0% ( 21 /28) 和33. 3% ( 4 /12) , 其差異有統計學意義( P < 0. 05) 。大腸癌腸壁、腸外
浸潤組間的CT 強化程度、MVD、VEGF 和MMP-2 的表達比較差異有統計學意義( P < 0. 05) 。CT 強化
程度與MVD 之間呈正相關( P < 0. 05) 。結論 SCT 增強掃描能較準確地判斷大腸癌的腸外浸潤, 且
腸外浸潤預示著更高的轉移傾向; CT 強化程度可作為定量分析指標初步判斷腫瘤血管生成, MVD、
VEGF、MMP-2 表達與大腸癌浸潤密切相關, 腫瘤血管生成在大腸癌的浸潤過程中起著促進作用。
【關鍵詞】 結腸腫瘤; 新生血管化, 病理性; 內皮生長因子; 體層攝影術, X 線計算機
Corr elation between spir al CT feat ur es of pericolic infiltra tion and tumor a ngiogenesis in color ecta l
car cinoma ZHANG Rui-ping, LI Jian-ding. Depa rtment of Radiology, the First Hospital of Shanxi
Medical University , Ta iyuan 030001, China
【Abstra ct 】 Objective To investigate the correlation of spiral CT ( SCT) features with pathology、
microvessel density ( MVD ) 、expression of vascular endothelial growth factor ( VEGF ) 、matrix
metalloproteinase-2( MMP-2 ) in colorectal carcinoma. Methods Forty patients with colorectal carcinoma
confirmed by operation were examined by SCT. The resected tumor specimens were immunohistochemically
stained for the expression of VEGF、MMP-2 and the calculation of MVD. Results The accuracy of SCT in
depicting the pericolic and wall infiltration was 92. 5% . The metastasis rates of colorectal cancer with
pericolic infiltration and wall infiltration were 75. 0% and 33. 3% , respectively, the differences were
statistically significant between the two groups( P < 0. 05) . The differences of CT enhancement value, MVD,
expressions of VEGF and MMP-2 between the two groups were statistically significant ( P < 0. 05 ) . The
enhancement degree of CT had a positive correlation with MVD ( P < 0. 05) . Conclusion SCT is accurate
for depicting pericolic and wall infiltration, pericolic infiltration in colorectal carcinoma indicates the
tendency of metastasis. The enhancement degree of CT might be used to quantitatively evaluate the tumor
angiogenesis, expressions of VEGF and MMP-2 and MVD are closely correlated with the infiltration of
colorectal cancer.
【Key words】 Colonic neoplasms; Neovasularization, pathologic; Endothelial growth factors;
Tomography, X-ray computed

大腸癌腸外浸潤螺旋CT 征象與腫瘤血管生成的相關性--腹部.rar