動態(tài)增強(qiáng)CT 功能成像評價肺癌腫瘤血管
生成的研究
周華 張敏鳴 肖圣祥 王麗君 周敏 鄒煜
【摘要】 目的 使用動態(tài)增強(qiáng)CT 功能成像( DCE-CT) 方法評價肺癌腫瘤血管生成。方法 對
34 例肺癌進(jìn)行動態(tài)CT 掃描, 記錄強(qiáng)化峰值( PH) 、腫塊強(qiáng)化達(dá)到峰值時間( Tp ) , 計算腫塊與主動
脈強(qiáng)化峰值之比( M/A) 、灌注值、相對血管容積( rBV) 和毛細(xì)血管通透值( Pm) , 將各值分別與肺癌微
血管密度( MVD) 做相關(guān)性分析; 將34 例肺癌分為血管內(nèi)皮生長因子( VEGF) 表達(dá)陽性組和VEGF 表
達(dá)陰性組, 分析2 組MVD、各成像參數(shù)以及淋巴結(jié)轉(zhuǎn)移情況的差異。結(jié)果 PH、M/A 、灌注值、rBV、
Pm 分別為( 26. 17 ±9. 17 ) HU、0. 12 ±0. 05、( 0. 31 ±0. 08 ) ml ·min - 1 ·ml - 1 、( 26. 85 ±11. 52) % 、
( 191. 20 ±132. 65) μl·min - 1 ·ml - 1 。PH、M/A 、灌注值、rBV 與MVD 呈正相關(guān), 其中灌注值與MVD
相關(guān)性最高( r = 0. 76, P < 0. 0001 ) , Pm 值與MVD 無相關(guān)性( r = 0. 30, P > 0. 05 ) ; VEGF 陽性組
MVD 和CT 功能成像參數(shù)高于VEGF 陰性組, 兩組淋巴結(jié)轉(zhuǎn)移情況差異有統(tǒng)計學(xué)意義( χ2 = 9. 409,
P < 0. 05) 。結(jié)論 DCE-CT 技術(shù)可獲得較為全面的肺癌血供信息, 有望成為評估肺癌腫瘤血管生成
的新方法。
【關(guān)鍵詞】 肺腫瘤; 新生血管化, 病理性; 體層攝影術(shù), X 線計算機(jī); 圖像處理, 計算機(jī)
輔助
Dynamic contra st-enhanced computed tomogr aphy functional imaging for the evaluation of tumor
a ngiogenesis in patients with lung ca rcinoma ZHOU Hua , ZHANG Min-ming, XIAO Sheng-xiang,
WANG Li-jun, ZHOU Min, ZOU Yu. Department of Radiology, The First Affiliated Hospita l, Medica l
College, Zhejia ng University, Hangzhou 310003, China
Corresponding author: ZHANG Min-ming, Email: zhangminming@163. com
【Abstra ct 】 Objective To investigate the role of dynamic contrast-enhanced computed tomography
( DCE-CT) in the evaluation of tumor angiogenesis in patients with lung carcinoma. Methods 34 patients
with pathology-proved pulmonary carcinoma underwent DCE-CT scan before operation. The functional
imaging parameters: peak height( PH) , the time of peak height ( Tp) , the ratio of PH of the mass to aorta
( M/A) , perfusion, the relative blood volume ( rBV) and permeability ( Pm) were calculated and correlated
with the microvessel density ( MVD) of the carcinoma. The functional imaging parameters MVD and the
lymph node involvement between VEGF positive group and VEGF negative group were analyzed.
Results The Perfusion, PH, M/A and rBV correlated positively with MVD ( r = 0. 76, 0. 67, 0. 70, 0. 65
respectively; P < 0. 0001) , and no significant correlation was found between Pm and MVD ( r = 0. 30, P >
0. 05 ) . The functional imaging parameters and MVD of VEGF positive group were higher than those of VEGF
negative group ( P < 0. 05) and the difference of lymph node involvement between two groups was significant
( χ2 = 9. 409, P < 0. 05) . Conclusion DCE-CT functional imaging technique provides general information
of lung carcinoma angiogenesis and alternates non-invasive option for evaluation of tumor angiogenesis in
patients with lung carcinoma.
【Key wor ds】 Lung neoplasms; Neovascarization, pathologic; Tomography, X-ray computed;
Image processing, computer-assisted

動態(tài)增強(qiáng)CT 功能成像評價肺癌腫瘤血管--胸部.rar